Increased left ventricular end-diastolic pressure is associated with impaired subendocardial myocardial perfusion in aortic stenosis

Abstract

Background: Aortic stenosis (AS) is characterized by impaired myocardial perfusion, particularly in the sub-endocardium, which can be detected non-invasively through cardiovascular magnetic resonance (CMR) quantitative stress perfusion mapping. Elevated left ventricular end-diastolic pressure (LVEDP), resulting from left ventricular hypertrophy and fibrosis, reduces coronary perfusion pressure (CPP) impairing myocardial perfusion. This study aims to evaluate whether impaired myocardial perfusion in AS is associated with invasively measured LVEDP.