Knowledge GAPPS: a case report of a rare inherited gastric cancer syndrome.

Abstract

A 66-year-old patient presented to a clinic to be investigated for a diagnosis of gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). GAPPS is a rare, autosomal-dominant syndrome manifesting with extensive polyposis of the stomach and predisposes patients to gastric adenocarcinoma. Gastroscopy and biopsy confirmed a diagnosis of GAPPS, showing polyposis in a typical antrum-sparing distribution. Due to the rarity of GAPPS, accepted management pathways remain contentious, especially regarding if and when to advise gastrectomy to minimise the risk of malignant polyp transformation. Moreover, the similarity in presentation of GAPPS and other stomach polyposis syndromes raises concerns about missed cases and lack of follow-up.