Prediction of prolonged ventilator dependence in preterm infants
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Authors
Ali, Kamal
Kagalwalla, Sabena
Cockar, Iram
Williams, Emma E
Tamura, Kentaro
Dassios, Theodore
Greenough, Anne
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Issue Date
2019
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Article
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Abstract
Volutrauma is an important factor in the pathogenesis of bronchopulmonary dysplasia (BPD). Our aims were to identify risk factors in the first 24 h for prolonged ventilator dependence and assess volume delivery and carbon dioxide levels in infants with evolving BPD. A retrospective study was undertaken of 41 infants born at less than 32 weeks of gestational age (GA). A higher tidal volume, minute volume and resistance and a lower GA, birth weight and compliance were associated with a significantly higher risk of ventilator dependence at 28 days. The strongest relationships were with birth weight (area under the receiver operating characteristic curve, AUROC = 0.771) and GA (AUROC = 0.813). Tidal volume remained significantly higher after adjusting for GA in those who remained ventilator dependent at 28 days. The 18 who remained ventilator dependent at 28 days had increased mean carbon dioxide (PCO
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European Journal of Pediatrics
Volume
178
Issue
7