Enhanced Complete Clot Ingestion with the ALGO Smart Pump: Preclinical Evidence Supporting Aspiration Efficiency in Mechanical Thrombectomy
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Mitchelle, Amer
Bhogal, Pervinder
Gandhi, Ravi
Slazas, Robert
Hanser, Manning
Manning, Nathan
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2026
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PURPOSE: To compare the ALGO Smart Pump (ALGO), operating in Adaptive Pulsatile Aspiration (APA™) and Static modes, with the Penumbra ENGINE during in-vitro mechanical thrombectomy, and to determine whether adaptive pulsatile aspiration improves complete clot ingestion (CCI) and reduces aspiration time across catheters sizes and catheter-to-artery (C/A) ratios. METHODS: A pre-specified integrative analysis of two previously completed in-vitro thrombectomy studies was conducted using a standardized middle cerebral artery occlusion model. A total of 720 thrombectomy procedures were performed by two experienced operators using twelve commercial catheters (six small-bore, six large-bore). Three aspiration modalities were tested: ALGO APA™, ALGO Static, and Penumbra ENGINE continuous aspiration (n = 30 per catheter-pump pairing). The primary endpoint was CCI; secondary endpoint was aspiration time. Outcome analysis included two-way ANOVA and Chi-squared tests, with catheter, operator, and C/A ratio terms. RESULTS: The ALGO demonstrated a higher median CCI rate than Penumbra (81.4% vs. 56.1%, ?(2)(1) = 52.364, p < 0.001). Aspiration times were significantly shorter with ALGO, particularly in APA™ mode (43.8 s vs. 60.6 s, p < 0.001). Two-way ANOVA demonstrated significant interaction between catheter size and pump type (p < 0.001), with ALGO notably improving small-bore catheter performance. CCI correlated positively with catheter-to-artery (C/A) ratio across both systems, with ALGO maintaining higher success across all ratios. CONCLUSION: Adaptive pulsatile aspiration enhances clot ingestion efficiency and reduces aspiration time in an in-vitro thrombectomy model, particularly for smaller catheters. These findings support further translational studies on optimizing aspiration dynamics to enhance first-pass success in endovascular stroke therapy.
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Clinical neuroradiology