Early Aortic Valve Replacement Versus Conservative Management: A Meta-Analysis of Randomized Controlled Trials.

Abstract

•Early aortic valve replacement before the development of severe symptomatic aortic stenosis is not associated with a benefit for most hard endpoints including mortality and myocardial infarction but is associated with a benefit in stroke. •The mechanism for the potential benefit of early aortic valve replacement on stroke remains unclear. •Younger patients and women may derive a mortality benefit from early aortic valve replacement, but this warrants further study.