Acute hepatitis of unknown aetiology in children – a clinical update on the recent outbreak with mechanistic insights
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Authors
Vimalesvaran, Sunitha
Verma, Anita
Kyrana, Eirini
Deheragoda, Maesha
Dhawan, Anil
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Issue Date
2023
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Article
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Abstract
Since April 2022, over 1000 children across 35 countries have developed episodes of acute hepatitis of unknown origin. At King's College Hospital, a total of 65 children were referred with acute hepatitis of unknown etiology, with 10 of these children presenting with acute liver dysfunction leading to acute liver failure. Multiple hypotheses have been proposed and continue to be investigated worldwide. In this review, we explore the current understanding of potential aetiologies for this outbreak. We further characterize the proposed immunological mechanisms of liver injury in these cases.
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Clinical and Experimental Immunology
Volume
212
Issue
1