Lipiodol: Properties, Applications, and Considerations in Interventional Radiology

Abstract

Lipiodol: Properties, Applications, and Considerations in Interventional Radiology Learning Objectives Describe the chemical composition and physical properties of Lipiodol. Discuss the role of Lipiodol in interventional radiology. Identify safety considerations and potential complications associated with Lipiodol use. Discuss emerging applications of Lipiodol. Background Lipiodol is an iodinated poppy seed oil widely utilised in interventional radiology for both diagnostic and therapeutic purposes. Its unique chemical properties, including high radiodensity, lipophilicity, and slow washout, make it particularly valuable in imaging and targeted therapeutic applications. Understanding its pharmacokinetics and biological behavior is essential for optimising its clinical use. Findings/Procedure Details Following a review of literature we provide a brief overview of current use cases of Lipiodol in interventional radiology such as hepatic interventions, lymphangiography, and musculoskeletal procedures. A foundational understanding of Lipiodol is critical to optimise clinical outcomes. Emerging innovations, including Lipiodolbased drug formulations and its expanding role in precision medicine and targeted intra-arterial therapies, continue to enhance its utility in interventional oncology and related fields. Conclusion Lipiodol remains a cornerstone in interventional radiology, offering diagnostic and therapeutic versatility and is likely to play a growing role in precision medicine and minimally invasive cancer therapies, further strengthening its value in interventional oncology.