TCT-573 The Impact of Hypertension on the Burden of Ischemic Heart Disease in the United States: Temporal Analysis of the Past 3 Decades
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Abdulelah Z.
Abdulelah, A.
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2025
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Background: Ischemic heart disease (IHD) imposes a significant global burden due to the associated morbidity and mortality. Hypertension is a known risk factor of IHD and negatively impacts outcomes. Accordingly, it is if of vital importance to evaluate the temporal trends in the mortality and disability adjusted-life years (DALY) of IHD that is attributed to hypertension to enable risk stratification and targeted therapies. Method(s): Data from the Global Burden of Disease database was retrieved to evaluate the temporal trends in the age-standardized mortality rate (ASMR) and age-standardized DALY rate (ASDR) of IHD that is attributed to hypertension in the US over the period 1990-2021. Joinpoint analysis was performed to calculate the Annual Percent Change (APC) and the Average Annual Percent Change (AAPC). Result(s): Over the period 1990-2021, an estimated total of 16,872,006 IHD-related deaths were reported in the US with hypertension attributing to 51.9% of those deaths. A statistically significant decline in IHD ASMR that is attributed to hypertension was observed in the US with an AAPC of -3.25 (95%CI -3.33 to -3.17, p<0.001). Gender stratification revealed a statistically significant decline in both, males (AAPC -3.38, 95%CI -3.44 to -3.31, p<0.001) and females (AAPC -3.22, 95%CI -3.30 to -3.17, p<0.001). Stratification at state level revealed a statistically significant decline across all states with the highest decline noted in Oregon (AAPC -3.87) followed by Massachusetts (AAPC -3.84), Minnesota (AAPC -3.74) and New Jersey (AAPC -3.62). The lowest decline was observed in Arkansas (AAPC -2.19). In regard to the ASDR, a statistically significant decline was witnessed in the US with an AAPC of -3.25 (95%CI -3.31 to -3.17, p<0.001). Stratification by gender also revealed a statistically significant decline in the ASDR in both, males (AAPC -3.26, 95%CI -3.31 to -3.20, p<0.001) and females (AAPC -3.25, 95%CI -3.31 to -3.19, p<0.001). Conclusion(s): Overall, the US experienced a significant decline in the impact of hypertension on the burden of IHD across all of its states and in both, males and females. Further evaluation of this decline is warranted to further establish the predisposing factors. Categories: CORONARY: Acute Coronary Syndromes Copyright © 2025
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Journal of the American College of Cardiology
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Transcatheter Cardiovascular Therapeutics Abstracts.