Musculoskeletal manifestations of diabetes mellitus - an update
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Authors
Ward H.
Jawad A.S.
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Issue Date
2026
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Article
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Abstract
Diabetes mellitus is an increasingly prevalent condition, with an estimated 1.3 billion people projected to be affected by 2050, and can reduce life expectancy by up to 20 years. Musculoskeletal complications are present in more than half of patients with diabetes and lead to significant morbidity and disability. Diabetes increases chronic inflammation, reduces anabolism and compromises blood supply to bones, muscles and joints. This can cause fibrosis of tendons and joints, impaired quality of bone and muscle production and, in some instances, local joint destruction. The risk is further increased in patients with overlapping metabolic syndrome. Musculoskeletal complications promote a sedentary lifestyle and worsen the trajectory of diabetes management. Here, we provide an update on the musculoskeletal manifestations of diabetes and their treatments since our review in 2015.Copyright © 2025 The Author(s)
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Clinical Medicine, Journal of the Royal College of Physicians of London
Volume
26
Issue
1