Identifying Novel Renal Biomarkers to Improve the Clinical Phenotyping of Preeclampsia

Abstract

Introduction: Preeclampsia (PE) is associated with acute kidney injury, carrying an increased risk of future renal disease. Whilst serum creatinine informs the diagnosis of PE, renal biomarkers are not routinely used for prediction and prognosis of PE. Magnetic resonance imaging (MRI) biomarkers can non-invasively quantify tissue characteristics such as inflammation, oedema and fibrosis. We evaluated maternal renal MRI biomarkers in women at high risk of developing PE to see if they could provide mechanistic insight and improved risk stratification in PE.