Overview of new targets for hepatitis B virus: immune modulators, interferons, bifunctional peptides, therapeutic vaccines and beyond
No Thumbnail Available
Authors
Lok, James
Guerra Veloz, Maria Fernanda
Agarwal, Kosh
Check for full-text access
Issue Date
2023
Type
Article
Language
Keywords
Alternative Title
Abstract
Nucleos(t)ide analogs are the cornerstone of treatment against hepatitis B virus; however, they have no direct effect on its transcriptional template (ie, covalently closed circular DNA) and so functional cure is rarely achieved. Over recent years, there has been a significant improvement in our understanding of the viral life cycle and its mechanisms of immune evasion. In this review article, we will explore novel therapeutic targets, discuss the latest data from clinical trials, and highlight future research priorities.
Description
Citation
Publisher
License
Journal
Clinics in Liver Disease
Volume
27
Issue
4