Does local infiltration analgesia in total joint arthroplasty offer any protection from prosthetic joint infections? An invitro experimental study
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Authors
Tandra, Varun
Koti, Manjunath
Kohli, Sandeep
Atta, Mustafa
Khanal, Prakash
Khan, Osman
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Issue Date
2023
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Article
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Abstract
UNLABELLED: Many local anaesthetic agents are now reported to have anti-microbial properties in various studies, and this ability to inhibit microbial growth is not uniform. As local anaesthetics are commonly infiltrated into the surgical field for perioperative pain management, it is very important to know if this practice offers any protection against surgical site infections. METHODS: In this study, three of the most common prosthetic joint infection-causing organisms, namely, RESULTS: The local anaesthetic agents tested could not inhibit the growth of any of the microorganisms. As there was no inhibition of bacterial growth in the experiment with the above three agents, further experiment with a diluted mixture was not performed. CONCLUSIONS: It can be concluded that local infiltration of anaesthetic agents is less likely to provide any perioperative protection against prosthetic joint infections but may interfere with some diagnostic tests for microbiology.
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Journal of Perioperative Practice
Volume
33
Issue
10