1006 Identifying H&E-based Immune Patterns in Endometrial Carcinoma and Their Association with Clinicopathologic Variables, Tumor Mutational Landscape, and Survival

Abstract

Disclosures: Merve Kaya: None; Lawrence Lin: None; Melanie Powell: None; Emma Crosbie: None; Alexandra Leary: None; Linda Mileshkin: None; Lois Shepherd: None; Marco Bruyn: None; Carien Creutzberg: None; Nanda Horeweg: None; Alicia Leon del Castillo: None; Carlos Parra-Herran: None; Vincent Smit: None; Marisa Nucci: None; Tjalling Bosse: None Background: As the current risk stratification for endometrial carcinoma (EC) lacks integration with the tumor immune microenvironment, and immune checkpoint inhibitors gain importance in EC treatment, a standardized method for assessing tumor-infiltrating lymphocytes will become relevant. Therefore, we aimed to develop and validate a pragmatic H&E-based immune scoring method to identify immune patterns in EC and assess associations with clinicopathologic variables, genetic alterations, and survival.