Alternate-day dosing to taper antidepressants risks severe withdrawal effects: an in silico analysis
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Authors
O'Neill, James R.
Sørensen, Anders
Taylor, David
Horowitz, Mark
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Issue Date
21/08/2025
Type
Journal article
Language
Keywords
Mental Health
Alternative Title
Abstract
Dosing every other day is likely to cause withdrawal effects with the antidepressants examined in this study. These recommendations remain theoretical until further clinical research and empirical validation of our proposed antidepressant tapering regimens.
Description
Citation
Journal of Affective Disorders,
Volume 392,
2026,
120084,
ISSN 0165-0327,
https://doi.org/10.1016/j.jad.2025.120084
Publisher
License
Journal
Journal of Affective Disorders
Volume
392