TCT-309 Temporal Trends in the Incidence and Mortality of Congenital Heart Disease in Europe Over 3 Decades
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Abdulelah A.
Abdulelah, Z.
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2025
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Article
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Background: Congenital heart disease imposes significant global health and socioeconomic burden due to the associated morbidity, impaired quality of life, and mortality. Therefore, thorough evaluation of the temporal trends in the incidence and mortality of congenital heart disease in Europe is of paramount significance to enable risk stratification. Method(s): Temporal trends in the incidence and mortality of congenital heart diseases across Europe over the period 1990-2019 were evaluated by retrieving data, including the age-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR) from the Global Burden of Disease database. Joinpoint analysis software was used to calculate the Annual Percent Change (APC) and Average Annual Percent Change (AAPC). Result(s): During 1990-2019, an estimated total of 3,592,801 congenital heart disease cases with a male predominance of 52.0% were reported across Europe. A statistically significant increase in the ASIR was noted across Europe with an AAPC of 0.019 (95%CI 0.007 to 0.260, p=0.002). Interestingly, gender stratification revealed a statistically significant increase in the ASIR in males with an AAPC of 0.04 (95%CI 0.033 to 0.049, p<0.001) and a statistically significant decline in females with an AAPC of -0.022 (95%CI -0.031 to -0.012, p<0.001). Stratification by region, Central Europe demonstrated a statistically significant decline in the ASIR with an AAPC of -0.042, whereas Eastern and Western Europe witnessed statistically significant increase in the ASIR, with the latter experiencing a more prominent increase (AAPC 0.23). In terms of mortality, an estimated total of 609,289 deaths with a male predominance of 57.3% were reported across Europe. A statistically significant decline in the ASMR was noted with an AAPC of -4.44 (95%CI -4.47 to -4.41, p<0.001). Stratification by region revealed a statistically significant decline across all regions with Central Europe experiencing the highest decline (AAPC of -4.27). Conclusion(s): Overall, the incidence of congenital heart disease appears to be increasing across Europe whereas mortality is on the decline. These findings warrant further evaluation to determine the factors associated with these trends. Categories: STRUCTURAL: Congenital and Other Structural Heart Disease Copyright © 2025
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Journal of the American College of Cardiology
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Transcatheter Cardiovascular Therapeutics Abstracts.