COVID-19 leukoencephalopathy with subacute magnetic resonance imaging findings of vasculitis and demyelination
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Authors
Vahedi, Ali
Apap Mangion, Sean
Silber, Eli
Sibtain, Naomi
Chandra, Julie
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Issue Date
2021
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Article
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Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) commonly results in a respiratory illness in symptomatic patients; however, those critically ill can develop a leukoencephalopathy. We describe two patients who had novel subacute MRI findings in the context of coronavirus disease 2019 (COVID-19) leukoencephalopathy, which we hypothesize could implicate a potent small-vessel vasculitis, ischemic demyelination and the presence of prolonged ischemia. Recent evidence of the direct neuroinvasiness of SARS-CoV-2 leading to ischemia and vascular damage supports this hypothesis.
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Journal of NeuroVirology
Volume
27
Issue
4