Wcn24-1827 Tuberculosis -Observational Study in a nephrology tertiary care centre at Kidney Foundation Hospital and Research Institute, Bangladesh

Abstract

Introduction: Tuberculosis (TB) is one of the major causes of death worldwide with an estimated 10 million cases and 1.2 million deaths in 2018. About a quarter of the world's population has been infected with M. tuberculosis. TB was the leading cause of death from a single infectious agent, ranking above HIV/AIDS up until the coronavirus (COVID-19) pandemic. TB affects people from the entire world, but over 95% of cases and deaths are from developing countries like Bangladesh which ranked seventh in overall highest incidence. The estimated incidence of TB in Bangladesh per 100,000 is 221 in, with a mortality rate of 24 per 100,000 population. Patients with chronic kidney disease (CKD) are at high risk for development or reactivation of tuberculosis (TB). TST is widely used in Bangladesh because of its low cost. However, in CKD patients, the sensitivity of this test is uncertain. A study performed in Kidney Foundation, Bangladesh showed low reactivity and high anergy in CKD patients. It is found that TST reliability is significantly low when compared with IGRA in CKD patients.