Closed-loop automated oxygen control in late preterm and term, ventilated infants: a randomised controlled trial
No Thumbnail Available
Authors
Kaltsogianni, Ourania
Jenkinson, Allan
Harris, Christopher
Jeffreys, Eleanor
Sikdar, Oishi
Greenough, Anne
Dassios, Theodore
Check for full-text access
Issue Date
2025
Type
Article
Language
Keywords
Alternative Title
Abstract
AIM: To compare the time spent above the target oxygen saturation range (SpO METHODS: Infants were randomised to receive CLAC or manual oxygen control from recruitment and within 24 h of mechanical ventilation until successful extubation. RESULTS: Forty infants with a median (IQR) gestational age of 37.4 (35.9-38.5) weeks were studied at a corrected postmenstrual age of 37.6 (36.0-38.7) weeks. In infants randomised to CLAC (n = 18) the time spent above the target oxygen saturation range was reduced by 20% (p < 0.001), and the time spent in the target range (92%-96%) was increased by 32% (p < 0.001) and the time spent in hyperoxia was reduced (p = 0.003). CLAC reduced the time spent in hypoxemia (SpO CONCLUSION: CLAC in ventilated infants born at or near term was associated with reduced time spent in hyperoxemia, more time spent in the target oxygen range, and fewer manual adjustments to the FiO
Description
Citation
Publisher
License
Journal
Acta Paediatrica
Volume
114
Issue
6