Epigenetic and Metabolic Reprogramming of Fibroblasts in Crohn's Disease Strictures Reveals Histone Deacetylases as Therapeutic Targets
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Background and Aims: No effective therapeutic intervention exists for intestinal fibrosis in Crohn's disease CD]. We characterized fibroblast subtypes, epigenetic and metabolic changes, and signalling pathways in CD fibrosis to inform future therapeutic strategies.
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Journal of Crohn's and Colitis
Volume
18
Issue
6