Males with sickle cell disease have higher risks of cerebrovascular disease, increased inflammation and a reduced response to hydroxyurea
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Authors
Di Mauro, Margherita
El Hoss, Sara
Nardo‐Marino, Amina
Stuart‐Smith, Sara
Strouboulis, John
Gibson, John S.
Rees, David C.
Brewin, John N.
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Issue Date
2023
Type
Article
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Abstract
Biological sex is important. Male sex is associated with worse outcomes in most measures, including cerebrovascular disease, hospital admissions, and blood transfusions, but not survival. Females also appear to have a better response to hydroxyurea therapy, reduced markers of inflammation, and better liver function.
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Journal
American Journal of Hematology
Volume
98
Issue
11