Genomic links between symptoms of eating disorders and suicidal ideation
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Authors
Musial, A.
Foye, U.
Kakar, S.
Jewell, T.
Treasure, J.
Kalsi, G.
Smith, I.
Meldrum, L.
Bristow, S.
Marsh, I.
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Issue Date
19/02/2025
Type
Journal Article
Language
Keywords
Mental Health
Alternative Title
Abstract
Introduction There is an emerging need for plant-based options for home enteral tube feeding (HETF) patients, however their long-term efficacy and safety needs to be established. Methods Forty-one HETF patients (age: 51 years (SD 23); range 19-84 years; 54% male) participated in a multi-center, prospective, single-arm, open label, 13-month intervention study of a plant-based, high energy, high protein (2 kcaL/mL and 10 g protein/100 mL) enteral tube feed with or without added fiber (1.5 g/100 mL). Seventeen patients continued on the plant-based feed beyond day 28 (28 D) with a 6- and 13-month follow-up (6 M and 13 M). Outcomes included gastrointestinal tolerance (GI), anthropometrics, muscle strength and function (handgrip strength, 30-s chair stand test (30SCST)), dietary intake, total daily feed volume and time for feeding, and safety. Results Compared to patient's baseline feeding regimen, patients using the plant-based feed reported: greater absence of GI symptoms at all time points (+7-12%, p ≤ 0.04); a reduced incidence and intensity of GI symptoms: bloating, burping at 28 D ( p < 0.05) and constipation, flatulence at 13 M ( p < 0.05); improved physical function between 6 M and 13 M (+2 30SCST repetitions, p = 0.02), with maintenance of body weight, calf circumference and handgrip strength; total protein intake increased at all time points (+0.2-0.3 g/kg/day, p < 0.05); and total daily feed volume (−225 to −264 mL/day, p < 0.05) and estimated time for pump feeding (−2 h/day, p < 0.05) reduced at all time points. Discussion This longitudinal study highlights that a plant-based (vegan-suitable) high energy, high protein enteral tube feed has good tolerance in HETF patients, positive long-term effects on protein intake and potential benefits on physical function.
Description
Citation
European Psychiatry. 2025;68(1):e38. doi:10.1192/j.eurpsy.2025.25
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Journal
European Psychiatry
Volume
68
Issue
1