Optimising pre-eclampsia screening in Black women: a secondary analysis of data from non-intervention screening studies

Abstract

OBJECTIVE: To compare pre-eclampsia screening strategies among Black vs. White ethnicity women. METHODS: Using data from prospective non-intervention cohort studies in Europe, we evaluated pre-eclampsia risk in singleton pregnancies. Risk was determined by clinical risk factor screening ('clinical'), 'clinical' with Black ethnicity as a moderate-risk factor ('clinical-modified'), and the Fetal Medicine Foundation competing-risks model at 11-13 weeks' gestation ('model RESULTS: At 11-13 weeks, 61,174 pregnancies were screened; preterm pre-eclampsia occurred in 493 (0.8%). At an overall 11.2% screen-positive-rate, 'model CONCLUSIONS: The screening performance of the competing-risks model is superior to that of clinical risk factor screening without and with addition of Black ethnicity as a moderate clinical risk factor.