Metastatic Prostate Cancer of the Mandible - A Rare Case Report

Abstract

Introduction: Prostate cancer is one of the most common malignancies in men, frequently exhibiting a predisposition for bony metastasis, although metastasis to the mandible is rare. Only 1% of oral cancers are metastases. Metastatic tumors of the mandible are therefore a rarity with less than 10% originating from a prostatic primary. This report presents an unusual case of mandibular metastasis from prostate carcinoma, discovered incidentally during a pre-bisphosphonate therapy dental assessment. Method(s): A 60-year-old male with a confirmed diagnosis of prostate cancer and known bony metastasis (Metastatic Adenocarcinoma Prostate Presenting with Metastatic Spinal Cord Compression), was referred for oral assessment prior to initiating bisphosphonate therapy. He reported a 12-month history of asymptomatic buccal swelling, a draining sinus adjacent to lower right first molar, and right lower lip paraesthesia. Clinical examination revealed buccal and lingual expansion in the mandibular region. Result(s): Radiographic evaluation showed a significant radiolucency extending from the lower right first molar to the lower right second premolar, with an additional lytic lesion extending from the lower right second premolar to the lower left canine. Extraction of the lower right first molar and socket biopsy confirmed metastatic prostatic carcinoma. The patient was subsequently referred to his prostate cancer care team for radiotherapy. Conclusion(s): Although mandibular metastasis is rare, with prostatic origin even rarer, metastatic prostate carcinoma should be considered in the differential diagnosis for asymptomatic mandibular bony expansion in patients with a history of bony metastases from prostate cancer.Copyright © 2025