Pathway-based genetic risk score analyses identify biological pathways linking together hypertension and dementia-related cognitive impairment traits
No Thumbnail Available
Authors
Meirelles,O.
Cabrera,C. P.
Li,D.
Barnes,M. R.
Gupta,A. K.
Brown,M. J.
Munroe,P. B.
Caulfield,M. J.
Launer,L. J.
Warren,H. R.
Contact
Check for full-text access
Issue Date
2023
Type
Conference Proceedings
Language
Keywords
Alternative Title
Abstract
Introduction: Cerebral small vessel disease is highly prevalent and contributes to cognitive impairment and dementia in the elderly. Elevated blood pressure (BP) increases risk for cerebrovascular damage, but the related mechanisms are uncertain. Published studies show associations between BP polygenic risk scores (PRS) and brain-MRI (magnetic resonance imaging) endophenotypes of dementia. However, analyses of full genome-wide BP-PRS cannot reveal which biological pathways are involved.
Description
Citation
Publisher
License
Journal
Human Heredity