Left Ventricular and Biventricular Multipoint Pacing With Dynamic Atrioventricular Delays: 6-Month Cardiac Resynchronization Therapy Response
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Authors
Thibault, Bernard
Waddingham, Peter
Badie, Nima
Mangual, Jan O.
Richer, Louis-Philippe
McSpadden, Luke C.
Betts, Tim R.
Calò, Leonardo
Grieco, Domenico
Leyva, Francisco
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2026
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Abstract
BACKGROUND: The response to cardiac resynchronization therapy (CRT) can depend on when and where the right and left ventricles (RV, LV) are paced. Dynamic atrioventricular (AV) delays (SyncAV CRT, Abbott) and multi-site LV pacing (e.g., MultiPoint Pacing [MPP], Abbott) are features that may enhance CRT response. Their combined impact has not been evaluated in a chronic clinical setting. OBJECTIVE: Evaluate the 6-month echocardiographic and clinical response to SyncAV when combined with either biventricular MPP (MPP+SyncAV: RV + LV1 + LV2 pacing) or LV-only MPP (LVMPP+SyncAV: LV1 + LV2 pacing). METHODS: CRT-indicated patients with LBBB and intact AV conduction (PR 0.05 for all. CONCLUSIONS: The 6-month echocardiographic (ESV, EF) and clinical (NYHA class, QoL, Packer) response rates observed in LBBB patients were promising when SyncAV was combined with MPP, in both biventricular and LV-only pacing modes. TRIAL REGISTRATION: NCT03567096.
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Journal of cardiovascular electrophysiology