Impact of Risk-Reducing Hysterectomy on Health-Related Quality of Life in Lynch Syndrome Women: Prescores Study
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Authors
Oxley S.
Legood R.
Lake M.
Dibden A.
Brentnall A.
Whenham T.
Wei X.
Mansour L.
Kalra A.
Ganesan S.
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2026
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Conference Proceedings
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Introduction: Risk-reducing hysterectomy (RRH) is the most effective strategy for preventing endometrial-cancer (EC). Understanding health-related quality-of-life (HRQOL) after RRH is essential for counselling/decision-making and economic evaluations. Studies have not reported this. We estimate HRQOL and develop health-related utility-scores (HRUS) following RRH: overall and for pre/postmenopausal women. Methodology: Preventing Endometrial-Cancers: Comparing Risk-Reducing Strategies (PRESCORES) (ISRCTN17432105) is a cross-sectional UK-study of Lynch-syndrome (LS) women. Patients were recruited via regional-genetics/gynaecological/colorectal services across 25 UK-NHS hospitals and patient-groups (LSUK). EQ-5D (QOL), clinical, demographic data were collected. Multiple linear-regression with non-parametric bootstrapping evaluated mean-differences in EQ-5D HRUS between RRH and controls, overall and for pre/postmenopausal subgroups. QOL of LS-women was compared against general-population reference-values. Result(s): 1114(28%) of 4003 eligible LS-women were recruited: RRH = 529 (mean-age = 54.9 years), Controls = 585 (mean-age = 42.9 years). RRH group was older (p = 51 years vs. postmenopausal-controls (p = .65). Overall, HRUS for LS-women was similar to the England general-population (p = 0.94). Conclusion(s): We show, RRH decreases HRQOL, particularly in premenopausal (not post-menopausal) women. Overall, LS-women have similar HRQOL to general-population women. Our findings are critically important for counselling patients and health-economic evaluations for EC-prevention.
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International journal of cancer. Journal international du cancer