CD14+ CD15− HLA-DR− myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure
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Authors
Bernsmeier, Christine
Triantafyllou, Evangelos
Brenig, Robert
Lebosse, Fanny J
Singanayagam, Arjuna
Patel, Vishal C
Pop, Oltin T
Khamri, Wafa
Nathwani, Rooshi
Tidswell, Robert
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Issue Date
2018
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Article
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Abstract
OBJECTIVE: Immune paresis in patients with acute-on-chronic liver failure (ACLF) accounts for infection susceptibility and increased mortality. Immunosuppressive mononuclear CD14 DESIGN: Patients with ACLF (n=41) were compared with healthy subjects (n=25) and patients with cirrhosis (n=22) or acute liver failure (n=30). CD14 RESULTS: Circulating CD14 CONCLUSION: Immunosuppressive CD14
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Journal
Gut
Volume
67
Issue
6