Fulminant infective endocarditis with toxin-negative Corynebacterium diphtheriae in people with substance use experiencing homelessness, England, 2024 to 2025
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Authors
Patel T.
Anwar T.
Mavrogiorgou E.
Utjesanovic N.
Aryee A.
Litt D.J.
D'Aeth J.C.
Primus C.
Das S.
Karogiannis N.
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Issue Date
2025
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Article
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Abstract
Between July 2024 and January 2025, five male patients in their early20s to early50s were confirmed with infective endocarditis associated with non-toxigenic Corynebacterium diphtheriae in England. Three were known to have experienced homelessness. All five used non-intravenous recreational drugs. Disease progression was rapid, four patients required surgical intervention, one died. Whole-genome sequencing and multilocus sequence type (MLST) analysis identified four individuals as ST559. Clinicians and substance use services have been alerted and enhanced surveillance implemented. A prevalence study is planned. Copyright © 2025 European Centre for Disease Prevention and Control (ECDC). All rights reserved.
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Eurosurveillance
Volume
30
Issue
13