The East London Parkinson's disease project - a case-control study of Parkinson's Disease in a diverse population
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Authors
Zirra A.
Dey K.C.
Camboe E.
Waters S.
Haque T.
Huxford B.
Chohan H.
Donkor N.
Kahan J.
BenJoseph A.
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Issue Date
2025
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Article
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Abstract
There is a relative dearth of research on patients with Parkinson's disease (PD) from under-represented ethnic groups in the United Kingdom. The East London Parkinson Disease project seeks to understand the clinical manifestations and determinants of PD in a diverse population. Data on clinical features were collected, between 2019 and 2024. We assessed 218 patients with PD and 90 controls. Among them, 50% of patients and 64% controls identified as South Asian or Black. South Asian and Black patients had significantly worse motor scores compared to White patients (mean SD], 42.2 18.8], and 47.0 16.6] vs 35.2 16.4], p < 0.001 and p < 0.001). Cognitive impairment was more prevalent in South Asian (73%) and Black patients (75%) than in White patients (45%, p = 0.002). Our results suggest that patients with PD from South Asian and Black ethnic groups may have more severe motor and certain non-motor features, including cognitive impairment, compared to White patients. Copyright © The Author(s) 2025.
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npj Parkinson's Disease
Volume
11
Issue
1