Chronic kidney disease risk in African and Caribbean populations with HIV
No Thumbnail Available
Authors
Jose, Sophie
Hamzah, Lisa
Jones, Rachael
Williams, Debbie
Winston, Alan
Burns, Fiona
Phillips, Andrew N
Sabin, Caroline A
Post, Frank A
Ainsworth, Jonathan
Check for full-text access
Issue Date
2018
Type
Article
Language
Keywords
Alternative Title
Abstract
We conducted an observational cohort study of end-stage kidney disease (ESKD) in >7000 African and Caribbean people with HIV in the UK. Using Poisson regression and East Africans as the reference group, the adjusted incidence rate ratio (95% confidence interval) of ESKD was 3.14 (1.26-7.84) in Southern Africans, 6.35 (2.53-15.96) in West Africans, and 5.26 (1.91-14.43) in Caribbeans. Higher CD4 cell count and suppressed HIV replication were associated with reduced risk of ESKD. The risk of ESKD varied among HIV-positive people of African heritage, with the highest rates observed in those of West African descent.
Description
Citation
Publisher
License
Journal
The Journal of Infectious Diseases
Volume
218
Issue
11